Key Publications & Presentations

GlySens was founded on a rigorous experimental research approach and believes in maintaining a solid scientific basis for research and development. The following brief selections of publications and presentations by the company founders are illustrative of the scientific underpinnings of the company’s approach.

Selected Publications

Kumosa, LS, TL Routh, JT Lin, JY Lucisano, and DA Gough. “Permeability of subcutaneous tissues surrounding long-term implants to oxygen.” Biomaterials 35 (2014) 8287-8296.

Gough, DA, LS Kumosa, TL Routh, JT Lin, and JY Lucisano. “Function of an implanted tissue glucose sensor for more than 1 year in animals.” Science Translational Medicine 2, 42 (July 28, 2010): 42ra53.

Rahaghi, FN and DA Gough. “Blood Glucose Dynamics.” Diabetes Technology and Therapeutics 10, (2008) 81-94.

Rahaghi, FN and DA Gough. “Prediction of Blood Glucose from Previous Values: An Update.” Commentaries on Perspectives in Diabetes, vol. 3, R. Paul Robertson, ed., (2007), 128-135.

Gough, DA, “Development of the Implantable Glucose Sensor: An Update.” (Invited). Commentaries on Perspectives in Diabetes, vol. 2, R. Paul Robertson, ed., (2006), 195-202.

Rahaghi, FN and DA Gough. “Glucose Sensors.” Encyclopedia of Medical Devices and Instrumentation. Ed. John G. Webster. 2nd ed. 6 vols. New York: Wiley, 2006.

Makale, MT, PC Chen, and DA Gough. “Variants of the Tissue-sensor Array Window Chamber.” American Journal of Physiology – Heart and Circulatory Physiology 289 (2005): H57-65.

Makale, MT, MC Jablecki, and DA Gough. “Mass Transfer and Gas-Phase Calibration of Implanted Oxygen Sensors.” Analytical Chemistry 76 (2004): 1773-77.

Gough, DA, K Kreutz-Delgado, and TM Bremer. “Frequency Characterization of Blood Glucose Dynamics.” Annals of Biomedical Engineering 31 (2003): 91-97.

Makale, MT, JT Lin, RE Calou, AG Tsai, PC Chen, and DA Gough. “Tissue Window Chamber System for Validation of Implanted Oxygen Sensors.” American Journal of Physiology – Heart and Circulatory Physiology 284 (2003): H2288-94.

Gough, DA and TM Bremer. “Immobilized Glucose Oxidase in Implantable Glucose Sensor Technology.” Diabetes Technology and Therapeutics 2.3 (2000): 377-80.

Jablecki, M and DA Gough. “Simulations of the Frequency Response of Implantable Glucose Sensors.” Analytical Chemistry 72 (2000): 1853-59.

Bremer, TM and DA Gough. “Is Blood Glucose Predictable From Previous Values? A Solicitation for Data.” Diabetes 48 (1999): 445-51.

Selected Presentations

Lucisano, Joseph Y., Timothy L. Routh, and Robert L. Engler.  “Patient Preference Assessment of a Long Term Fully-Implantable Continuous Glucose Monitoring System.” Fourteenth Annual Diabetes Technology Meeting, Bethesda, MD, November 6-8, 2014, A69.

Gough, David A., Lucas S. Kumosa, Melinda M. Tong, Timothy L. Routh, Joe T. Lin, and Joseph Y. Lucisano. “Fully Implanted Sensors: Demise of the ‘Impermeable Tissue’ Hypothesis.”  The Tissue Response to Implanted Active Medical Devices Meeting, Herndon, Virginia, May 9-10, 2014.

Lucisano, Joseph Y., David A. Gough, Timothy L. Routh, Jennifer E. Lucisano, and Joe T. Lin. “Long Term, Fully-Implanted, Self-Contained Subcutaneous Glucose Sensor: Results from Clinical Evaluation and Applicability for Closed Loop Systems.” NIH Workshop on Innovation towards an Artificial Pancreas (2013).

Lucisano, Joseph Y., Timothy L. Routh, Marcus Hompesch, and Jennifer E. Lucisano. “Application of the Long Term Implantable Continuous Glucose Monitoring System in a Human Subject.” Twelfth Annual Diabetes Technology Meeting (2012) S37.

Gough, David A., Joe T. Lin, Timothy L. Routh, and Joseph Y. Lucisano. “Time Lag Stability of Long Term Subcutaneous Glucose Sensors in Animals.” American Diabetes Association 69th Scientific Sessions, New Orleans, LA, June 6-8, 2009.

Lucisano, Joseph Y., Joe T. Lin, Timothy L. Routh, and David A. Gough. “Long Term Results of a Subcutaneous Glucose Sensor in Animals.” Eighth Annual Diabetes Technology Meeting, Bethesda, MD, November 13-15, 2008.

Lucisano, Joseph Y., Joe T. Lin, Timothy L. Routh, Thomas G. Wallner, and David A. Gough. “Glucose Permeability in Tissues for Long Term Glucose Sensor.” Sixth Annual Diabetes Technology Meeting, Atlanta, GA, November 2-4, 2006.

Rahaghi, Farbod N., and David A. Gough. “Defining Normal Blood Glucose Dynamics. “Fifth Annual Diabetes Technology Meeting, San Francisco, CA, November 10-12, 2005.

Gough, David A., Peter C. Chen, Milan T. Makale, Jared B. Goor, Farbod N. Rahaghi, Joe T. Lin, and Joseph Y. Lucisano. “Detailed Validation of a Glucose Sensor Implanted in Tissue.” Fourth Annual Diabetes Technology Meeting, Philadelphia, PA, October 28-30, 2004.

Gough, David A. “Validation of Implantable Glucose Sensors.” Third La Jolla Conference on Glucose Monitoring and Control, La Jolla, CA, February 12-14, 2004.

Gough, David A. “Tissue Metabolite Sensors: Factors that Determine Their Signals.” Third Annual Diabetes Technology Meeting, San Francisco, CA, November 6-8, 2003.

Gough, David A. “Long Term Implanted Sensors for Glucose, Oxygen, and Lactate.” The Future of Metabolic Monitoring of Glucose (sponsored by NIH, NASA, DoD, JDRF), Alexandria, VA, May 21-22, 2002.